Diabetes is a dysmetabolic state(Abnormal metabolism) in which abnormal rise in blood glucose level. This leads to 2 important complications. One is called as macrovascular complications – acceleration of atherosclerosis (excess and early deposit of cholesterol in arteries. Another is microvascular complications which are characteristic of prolonged uncontrolled diabetes. They are peripheral neuropathy(damage of peripheral nerves), nephropathy(damage of glomerular apparatus), and retinopathy( damage of retina of eyes), Varying degree of genetic and environmental influences lead to this condition. Most important pathophysiological factors are gradual loss of Beta cell function (and cellular loss if not addressed in initial stages) and insulin resistance.